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RESUlTS 60 4% ; patients out of 142 were single while 75 52, 8% ; were married. 5 24, 6% ; patients had received elementary, 67 47, 2% ; high and 7 26, 1% ; superior level of education. 68 47, 9% ; patients were workers and employees, 24 16.9% ; were retired, 17 12% ; were students.82 57, 7% ; had moderate and 44 1% ; low income. 18 out of 142 had medical insurance 48 , 8% ; were inpatients of our hospital while 49 4, 5% ; were transferred from other hospital of Athens, 24 16, 9% ; from Greek province. The mean time until the admittance in our unit was 64, 4 56, days while 64, 8% were admitted the first two months. 77% had experienced some kind of mobilization before their admittance. At the admittance 14 9, ; patients had tracheostomy, 91 64, 1% ; indwelling catheter, 2, 1% ; gastrostomy, 21 14, 8% ; joint contractures. The complications were: 2 16, 2% ; pressure sores, 62 4, 7% ; urinary tract infection and 8 5, 6% ; lithiasis, 17 12% ; heterotopic ossification, 6 4, 2% ; thromboembolic disease, 18 12, 7% ; pain. Patient's functional evaluation, by Barthel index, had a mean 24, 217 at admittance and 64, 8 24, at discharge. Regarding the patients satisfaction the mean value was , 8050, 67 while their relative's one, was , 8200, 71. Conclusion: We consider that the above material and its data and characteristics are representative for supporting reliable conclusions, for instance, motilium over the counter.
1 INTRODUCTION A new interest in the function of the adipose tissue as an active endocrine organ capable of self-regulation by a feedback mechanism was launched by the positional cloning of the murine obese ob ; gene Zhang et al. 1994 ; . Previously it had been suggested that there might be a hormonal satiety factor originating from the adipose tissue and informing the animal about the amount of food intake necessary for survival Coleman 1973, Wilson et al. 1990 ; , and the protein product of the ob gene has proved to be this signal. The peptide hormone coded by the ob gene was thereafter given to genetically obese ob ob mice causing a reduction in food intake and weight loss Campfield et al. 1995, Halaas et al. 1995, Pelleymounter et al. 1995, Stephens et al. 1995 ; . The ob protein was therefore named leptin after the greek adjective ` [leptos], thin. These experiments encouraged the scientific community to an enthusiastic surge of leptin research. Mostly, this research has concentrated on mice and men with the ultimate goal of ameliorating human obesity and finding a substance for the treatment of overweight patients. In nature, however, avoiding obesity is far from being crucial to the survival of animals. Quite on the contrary, the periods of food shortage, inadequate nutrition and cold have to be overcome in order to survive and to be able to reproduce. The winter is a challenge for mammals living in the boreal climate. The low temperatures pose a threat to survival and the amount of available food diminishes in the period of time, when the demand for energy in the endotherms is at its peak. Therefore the animals store energy as fat, especially triacylglycerols. The homeostatic mechanisms of the mammalian body including the endocrine system, the hypothalamus and the autonomic nervous system control the body weight and try to keep it at a stable level. Ultimately, ecology and physiology are interconnected at a very basic level. Physiological signal substances, such as leptin, have evolved to ensure the survival of the animal until successful reproduction has been established. In comparative vertebrate physiology the functions of leptin should be considered in this context, which has been the main motivation for the undertaking of the studies of this thesis.
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