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Green MD and Tephly TR 1998 ; Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteins. Drug Metab Dispos 26: 860 867. Guerret M, Julien-Larose C and Lavene D 1981 ; Application de la chromatographie en phase gazeuse-colonnes capillaires a l'elucidation du metabolisme du ketotifene chez le singe et l'homme. Proceedings of the First European Congress of Biopharmaceutics and Pharmacokinetics Aiache JM and Hirtz J eds ; 1981 Apr 13; Paris 2: 317321. Hawes EM 1998 ; N -Glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group. Drug Metab Dispos 26: 830 837. Julien-Larose C, Guerret M, Lavene D and Kiechel JR 1983 ; Quantification of ketotifen and its metabolites in human plasma by gas chromatography mass spectrometry. Biomed Mass Spectrom 10: 136 142. Kassahun K, Mattiuz E, Franklin R and Gillespie T 1998 ; Olanzapine 10-N-glucuronide. A tertiary N-glucuronide unique to humans. Drug Metab Dispos 26: 848 855. Kassahun K, Mattiuz E, Nyhart E Jr, Obermeyer B, Gillespie T, Murphy A, Goodwin RM, Tupper D, Callaghan JT and Lemberger L 1997 ; Disposition and biotransformation of the antipsychotic agent olanzapine in humans. Drug Metab Dispos 25: 8193. Kellie GM and Riddell FG 1974 ; Non-chair conformations of six-membered rings, in Topics in Stereochemistry Eliel EL and Allinger NL eds ; vol 8, pp 225269, John Wiley & Sons, New York. Klaassen CD and Watkins JB III 1984 ; Mechanisms of bile formation, hepatic uptake and biliary excretion. Pharmacol Rev 36: 1 67. Le Bigot JF, Begue JM, Kiechel JR and Guillouzo A 1987 ; Species differences in metabolism of ketotifen in rat, rabbit and man: Demonstration of similar pathways in vivo and in cultured hepatocytes. Life Sci 40: 883 890. Le Bigot JF, Cresteil T, Begue JM, Kiechel JR and Beaune P 1983 ; Metabolism of ketotifen by human liver microsomes. In vitro characterization of a tertiary amine glucuronidation. Drug Metab Dispos 11: 585589. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ 1951 ; Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265275. Luo H, Hawes EM, McKay G and Midha KK 1992 ; Synthesis and characterization of.
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