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Those themes that drew the strongest response were around the helpfulness of people and organisations and the most useful forms of help they provided; the value of the website and its contents; what other services MSGV could offer; the impact of Meniere's disease on people's lives; the positive life changes produced by having Meniere's disease and medication issues. 6.1 Helpfulness of people and organisations. Receiving information was important to people with Meniere's disease. MSGV rated as the most helpful in terms of providing information about symptoms and symptom management. Meniere's Support Group was most helpful with prompt delivery of information, which I can refer to on a `bad day' or when symptoms have changed and articles I overlooked become more relevant to me, for example, selective estrogen receptor modulator. How to order contact us shopping cart generic vs brand product list acne products retin-a allergy allegra loratadine zyrtec view all 4 products singulair anabolic steroid nuberol antibacterial cipro anticoagulants coumadin anticonvulsant lamictal view all 2 products neurontin antidepressant zyban paxil view all 6 products effexor xr pamelor prozac zoloft antifungal lamisil arthritis arava asthma allegra loratadine zyrtec view all 4 products singulair blood pressure adalat coreg norvasc altace cozaar verapamil view all 15 products avapro cardura lasix lopressor lotensin monopril prinivil tenormin vasotec cancer nolvadex cardiovascular adalat coreg tiazac view all 6 products digiter plavix tenormin cholesterol lipitor tricor zocor view all 5 products mevacor pravachol diabetes actos amaryl glucophage view all 5 products avandia glucotrol xl hair loss propecia lifestyle cialis cialis soft tabs levitra viagra viagra soft tabs flomax - men's health cialis cialis soft tabs levitra propecia viagra viagra soft tabs flomax mental health seroquel paxil view all 3 products zoloft osteoporosis fosamax pain medications soma ultram view all 3 products celebrex skin care lamisil stomach zantac nexium prilosec view all 5 products prevacid protonix stop smoking zyban thyroid synthroid weight loss meridia view all 2 products phentermine woman's health evista fosamax imitrex nolvadex view all 5 products clomid alphabetical list: a b c generic plavix - clopidogrel generic plavix clopidogrel 75mg shape and color of the pill may differ from the image. However, the most exciting area of development in the hrt market involves serms, like lilly's evista.
1. Diagnose dementia and delirium 2. Diagnose specific psychiatric syndromes 3. Analyse behaviour for communication failures 4. Consider a cholinesterase inhibitor 5. Specific pharmacotherapy 6. Re-evaluate at least three monthly Behavioural and Psychological Symptoms of Dementia. Specialized labs to test for genetic defects on 2D6 and 2C19. Now the labs need to convince more doctors to order the tests. Pam Sherry, a spokeswoman for Roche's LabCorp, quoted a "ballpark retail" price of $1, 360 -- but said insurers that have contracts with LabCorp will probably pay less. But many policies -- including ones from Aetna, CareFirst BlueCross BlueShield and Cigna HealthCare -- won't pay at all, because the insurers consider use of the testing in clinical practice "experimental and investigational." UnitedHealthcare doesn't have a written policy on cytochrome P450 testing yet, says spokesman Steven Matthews, but the company's plans -- including M.D.-IPA and Optimum Choice -- may approve the testing on a case-by-case basis, if it's prescribed and used properly. Federal workers are guaranteed coverage for medically necessary testing, said Office of Personnel Management spokesman Michael Orenstein, because Federal Employees Health Benefit Plan contracts stipulate that FDA-approved tests may not be considered investigational. But do you really want your health insurance plan to pay for the testing? Cozza posed an interesting question: If your insurer learned that you had a CYP defect . could it decide to require preapproval for every prescription any doctor writes for you? No insurance plans are paying for routine genotyping yet. But the field of pharmacogenetics is young. "My prediction, " said Mrazek, "is that, down the line, pediatricians will do this testing during a child's infancy." But first the labs know they have some convincing to do. Lisa Barrett Mann has written previously for the Health section about Medicare drug benefits, autism and in vitro fertilization. Comments: health washpost . 2006 The Washington Post Company and flomax. 7. Vergote I, Robertson JFR, Kleeberg U et al. Postmenopausal women who progress on fulvestrant `Faslodex' ; remain sensitive to further endocrine therapy. Breast Canc Res Treat 2003; 79: 207-11 McKeage K, Curran MP and Plosker GL. Fulvestrant. A review of its use in hormone-receptor positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy. Drugs 2004; 64: 633-48 AstraZeneca UK Ltd. Faslodex. Summary of Product Characteristics. Mar 2004.

You may not be able to take evista, or you may require special monitoring or a dosage adjustment if you are taking any of the medicines listed above and flovent. I stopped taking it on the advise of an internal medicine doctor not the endocronologist that origionally prescribed it. DrUg nAMe Pituitary Agents -- continued oxytocin vasopressin Prostaglandins misoprostol Sex Hormones Modifiers ANDRODERM testosterone ; COMBIPATCH estradiol norethindrone ; danazol DEPO-PROVERA medroxyprogesterone depot ; ethinyl estradiol 20 desogestrel 0.15 ethinyl estradiol 20 levonorgestrel 0.1 ethinyl estradiol 20 norethindrone 1 ethinyl estradiol 30 desogestrel 0.15 ethinyl estradiol 30 norgestrel 0.30 ethinyl estradiol 30 norethindrone 1.5 ethinyl estradiol 35 ethynodiol 1 ethinyl estradiol 35 norethindrone 0.5 ethinyl estradiol 35 norethindrone 0.5-1 ethinyl estradiol 35 norethindrone 1 ethinyl estradiol 35 norgestimate 0.25 ethinyl estradiol levonorgestrel- triphasic ethinyl estradiol desogestrel- triphasic ethinyl estradiol norethindrone- triphasic ethinyl estradiol norgestimate- triphasic estradiol estradiol transdermal patch estropipate EVISTA raloxifene ; LUNELLE estradiol m-progesterone ; medroxyprogesterone acetate megestrol acetate MENEST estrogens, esterified ; mestranol 50 norethindrone 1 MIRENA levonorgestrel-releasing intrauterine system ; nandrolone decanoate norethindrone 0.35 norethindrone acetate NORPLANT levonorgestrel implant and fosamax.
K hler, H.: The nucleus in and the growth of hygroscopic particles, o Trans. Faraday Soc., 32, 11521161, 1936. Kolb, C. E., Davidovits, P., Jayne, J. T., Shi, Q., and Worsnop, D. R.: Kinetics of trace gas uptake by liquid surfaces, Prog. React. Kinet. Mec., 27, 146, 2002. Kumar, P. P., Broekhuizen, K., and Abbatt, J. P. D.: Organic acids as cloud condenstaion nuclei: Laboratory studies of highly soluble and insoluble species, Atmos. Chem. Phys., 3, 509520, 2003, : atmos-chem-phys 3 509 2003 . LaFranchi, B. W. and Petrucci, G. A.: Photoelectron resonance capture ionization PERCI ; : A novel technique for the softionization of organic compounds, J. Am. Soc. Mass Spectrom., 15, 424430, 2004. LaFranchi, B. W. and Petrucci, G. A.: A comprehensive characterization of photoelectron resonance capture ionization aerosol mass spectrometry for the quantitative and qualitative analysis of organic particulate matter, Int. J. Mass Spectrom., 258, 120133, 2006. LaFranchi, B. W., Zahardis, J., and Petrucci, G. A.: Photoelectron resonance capture ionization mass spectrometry: a soft ionization source for mass spectrometry of particle-phase organic compounds, Rapid Commun. Mass Spectrom., 18, 25172521, 2004. Ledea, O., Daz, M., Molerio, J., Jardines, D., Rosado, A., and Cori rea, T.: 1 H-NMR spectroscopy study of oleic acid and methyl oleate ozonation in different reaction conditions, Revista CENIC Ciencias Qumicas, 34, 38, 2003. i Lee, A. K. Y., Lau, A. P. S., Cheng, J. Y. W., Fang, M., and Chan, C. K.: Source identification analysis for the airborne bacteria and fungi using a biomarker approach, Atmos. Environ., in press, 2007. Lewin, A. G., Johnson, D., Price, D. W., and Marston, G.: Aspects of the kinetics and mechanism of the gas-phase reactions of ozone and conjugated dienes, Phys. Chem. Chem. Phys., 3, 12531261, 2001. Limbeck, A. and Puxbaum, H.: Organic acids in continental background aerosols, Atmos. Environ., 33, 18471852, 1999. Lohmann, U. and Feichter, J.: Global indirect aerosol effects: a review, Atmos. Chem. Phys., 5, 715737, 2005, : atmos-chem-phys 5 715 2005 . Lovejoy, E. R., Huey, L. G., and Hanson, D. R.: Atmospheric fate of CF3 OH 2: Heterogeneous reaction, J. Geophys. Res., 100, 18 77518 Mag, T.: Canola and Rapeseed. Production, Chemistry, Nutrition, and Processing Technology, Van Nostrand Reinhold, New York, 1990. Marks, R., Kruczalak, K., Jankowska, K., and Michalska, M.: Bacteria and fungi in air over the Gulf of Gdansk and Baltic Sea, J. Aerosol Sci., 32, 237250, 2001. Martin, S. T.: Interactive comment on "The oleic acid-ozone heterogeneous reaction system: products, kinetics, secondary chemistry, and atmospheric implications of a model system a review, " Atmos. Chem. Phys. Discuss., 6, S4979S4980, 2006a. Martin, S. T.: Interactive comment on "The oleic acid-ozone heterogeneous reaction system: products, kinetics, secondary chemistry, and atmospheric implications of a model system a review, " Atmos. Chem. Phys. Discuss., 6, S4975S4978, 2006b. Martinez, R. I., Herron, J. T., and Huie, R. E.: The mechanism of ozone-alkene reactions in the gas phase. A mass spectrometric study of the reactions of eight linear and branched-chain alkenes.
P. H. FREEDMAN, "La pagesia servil al segle XIII", dins Assaig d'histria de la pagesia catalana segles XI-XV ; , Edicions 62, Barcelona 1988, pp. 131-145 traducci de "Peasant servitude in the thirteenth century", La formaci i expansi del feudalisme catal, Estudi General, 5-6, Girona 1985-1986, pp. 437-445 ; . P. H. FREEDMAN, "Catalunya nova i Catalunya vella a l'edat mitjana: dues Catalunyes?", Revista de Girona, 118 1986 ; , pp. 432-435. P. H. FREEDMAN, Assaig d'histria de la pagesia catalana segles XI-XV ; , Edicions 62, Barcelona 1988. P. H. FREEDMAN, Els orgens de la servitud pagesa a la Catalunya Medieval, Eumo editorial, Vic 1993. L'original en angls va ser publicat el 1991 ; . R. GARCA CRCEL i M. V. MARTNEZ RUZ, Poblacin, jurisdiccin y propiedad del obispado de Gerona Siglos XIV-XVII ; , Colegio Universitario de Gerona. Universidad Autnoma de Barcelona, Gerona 1976. L. GARCA-GUIJARRO RAMOS, Datos para el estudio de la renta feudal maestral de la Orden de Montesa en el siglo XV, Institucin Alfonso el Magnnimo, Valencia 1978. B. GAR, El seoro de Ventall. Historia de las familias Requesens, Caramany y Perramn que lo poseyeron, Casa Perramn, Ventall 1989. P. GIFRE I RIBAS, "Servituds i prestacions pageses a l'poca moderna. L'exemple del domini de l'Almoina del Pa de la Seu de Girona 1486-1776 ; ", Recerques, nm. 30 1994 ; pp. 7-26. P. GIFRE I RIBAS i R. LLUCH BRAMON, "Continutats del mas catal abans i desprs de la Sentncia Arbitral de Guadalupe segles XV-XVI ; ", dins M. T. FERRER MALLOL, J. MUTG i M. RIU eds. ; , El mas catal durant l'edat mitjana i la moderna segles IX-XVIII ; , Consell Superior d'Invesigacions Cientfiques-Instituci Mil i Fontanals, Barcelona 2001, pp. 593-610 P. GIFRE I RIBAS i S. SOLER I SIMON, Patrimoni i Arxiu. Inventari del fons patrimonial Caramany de Cor. Segles XIII-XX, Collecci Fontanetum-2, La Bisbal d'Empord 1996. P. GIFRE I RIBAS i S. SOLER I SIMON, Els Farners: vassalls de senyors i senyors de pagesos. Catleg documental de l'Arxiu Farners, Consell Comarcal de la Selva-Centre d'Estudis Selvatans, Santa Coloma de Farners 1996. M. GOLOBARDES, Els remences dins el quadre de la pagesia catalana fins el segle XV, Ed. Biblioteca Palau de Peralada, 1973, 2 vols and furosemide.
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Congratulations ! Nitin Nayak, son of our Executive D i r Mr. Ganesh Nayak has passed the C.A. final examination with a rank and that too in the first attempt. Nitin did his articleship under the guidance of Mr. Mukesh Shah of M s Mukesh M Shah & Co.We wish him all the very best in his future endeavours. Quiz whiz Congratulations ! Marlon D'Souza, son of Ms. Gera D'Souza, API Division, attained the Apex position in Cadbury B o u Intraschool Quiz competition in December 2003. We wish this young and bright lad many more successes in the years to come. Keep it up Mr. Pradeep Sampath Kumar, son of Mr. A. K Sampath Kumar of Recon Healthcare is an upcoming cricketeer. He recently represented the Karnataka team in a match played against the visiting Sri Lankan `A' team. Pradeep has been a part of the Ceylon Indoor Cricket Association which held an Indoor cricket tournament last year at Sri Lanka. Good work Mr. Pranav Jogani of F&D department has been conferred a doctorate degree by the North Gujarat University. His doctoral thesis was titled - Investigation in coprocessed directly compressible adjuvant and their application in pharmaceutical tablets . Your photograph can be on our masthead ! The flowers that you see on the masthead of this issue of Zydan News is the Purple Trumpet flower. This tree has a very short flowering period of just 15 days and is generally seen in full bloom in the months of November and December. This photograph was clicked by Ms. Leena Sagar in Hyderabad in the year 2000. If you have any photographs of an interesting landscape that we could use on our masthead send it across to us with a small note. February, 2004 Volume 10 No. 1 and gemfibrozil.
Whether its a serm evista ; , bisphosphonate fosamax, actonel etc ; , or pth, plus calcium d magnesium and exercise. As a Counselor in their outpatient program. She suffers from schizophrenia and will speak about how she was able to overcome her disorder to lead a normal life and help others. Mr. Kevin McDonald has close family members who have mental illnesses. His presentation will give the perspective of the family member. Over the last three years, this forum has been a tremendous success. Despite competition from the World Series, the event has attracted a large crowd of mental health professionals, family members and consumers. Please join us on: October 18, 2000 7: p.m. Town Hall New City, NY In addition, this year's elementary school project will be at Evan's Park and glucophage.
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Q. Ye, J.L. McLaughlin * , and D. Evert, "Absolute Stereochemistries of Giganin and Loganin, Bioactive Non-Tetrahydrofuran Ring Annonaceous Acetogenins from Asimina longifolia, " Heterocycles 43, 1607-1512 1996 ; . D. Alfonso, H.A. Johnson, T. Colman-Saizarbitoria, C.P. Presley, G.P. McCabe, and J.L. McLaughlin * , "SARs of Annonaceous Acetogenins in Rat Liver Mitochondria, " Natural Toxins, 4, 181-188 and erratum 295 1996 ; . K. He, G. Shi, L. Zeng, Q. Ye, and J.L. McLaughlin * , "Konishiol, A Novel Sesquiterpene, and Bioactive Components from Cunninghamia konishii, " Planta Medica, 63, 158-160 1997 ; . Z.-M. Gu, D. Zhou, J. Wu, G. Shi, L. Zeng, and J.L. McLaughlin * , "Screening for Annonaceous Acetogenins in Bioactive Plant Extracts by Liquid Chromatography Mass Spectrometry, " Journal of Natural Products, 60, 242-248 1997 ; . J.L. McLaughlin * , T. Colman-Saizarbitoria, and J.E. Anderson, "Tres Bioensayos Simples para Quimicos de Productos Naturales, " Revista de la Sociedad Venezolana de Quimica, 18 4 ; , 13-18 1995 ; . G. Shi, J.F.Kozlowski, J.T. Schwedler, K.V. Wood, J.M. MacDougal, and J.L. McLaughlin * , "Muconin and Mucoxin: Additional Nonclassical Bioactive Acetogenins from Rollinia mucosa, " Journal of Organic Chemistry, 61, 7988-7989 1996 ; . K. He, G.-X.Zhao, G. Shi, L. Zeng, J.-F. Chao, and J.L. McLaughlin * , "Additional Bioactive Annonaceous Acetogenins from Asimina triloba Annonaceae ; , " Bioorganic and Medicinal Chemistry, 5, 501-506 1997 ; . D.C. Hopp, L. Zeng, Z.-M. Gu, J.F. Kozlowski, and J.L. McLaughlin * , "Novel MonoTetrahydrofuran Ring Acetogenins, from the Bark of Annona squamosa, Showing Cytotoxic Selectivities for the Human Pancreatic Carcinoma Cell Line, PACA-2, " Journal of Natural Products, 60, 581-586 1997 ; . F. Alali, L. Zeng, Y. Zhang, Q. Ye, D.C. Hopp, J.T. Schwedler, and J.L. McLaughlin * , "4-Deoxyannomontacin and 2, 4-cis and trans ; -Annomontacinone, New Bioactive MonoTetrahydrofuran Annonaceous Acetogenins from Goniothalamus giganteus, " Bioorganic and Medicinal Chemistry, 5, 549-555 1997 ; . J.L. McLaughlin * , L.L. Rogers, and J.E. Anderson, "The Use of Biological Assays to Evaluate Botanicals, " Drug Information Journal, 32, 513-524 1998 ; . H. Shimada, V.E. Tyler, and J.L. McLaughlin * , "Biologically Active Acylglycerides from the Berries of Saw-Palmetto Serenona repens, Palmae ; , " Journal of Natural Products, 60, 417-418 1997 ; . C.J. Njoku, D.C. Hopp, F. Alali, U. Asuzu, and J.L. McLaughlin * , "Dihydroguaiaretic acid: A Bioactive Component of the Stem Bark of Pyranthus angolensis Myristicaceae ; , " Planta Medica, 63, 580-581 1997 ; . C.J. Njoku, L. Zeng, I.U. Asuzu, N.H. Oberlies, and J.L. McLaughlin * , "Oleanolic Acid: A Bioactive Component of the Leaves of Ocimum gratissimum Lamiaceae ; , " International Journal of Pharmacognosy, 35, 134-137 1997 ; . Z.-M. Gu, D. Zhou, J. Wu * , G. Shi, and J.L. McLaughlin, "Isolation of New Bioactive Annonaceous Acetogenins from Rollinia mucosa Guided by Liquid Chromatography Mass Spectrometery, " Bioorganic and Medicinal Chemistry, 5, 1911-1916 1997 ; . N.H. Oberlies, V.L. Croy, M.H. Harrison, and J.L Laughlin * , "The Annonaceous Acetogenin Bullatacin is Cytotoxic Against Multidrug Resistant Human Mammary Adenocarcinoma Cells, " Cancer Letters, 115, 173-179 1997 ; . N.H. Oberlies, C.-J. Chang, and J.L. McLaughlin * , "Structure-Activity Relationships of Diverse Annonaceous Acetogenins against Multidrug Resistant Human Mammary Adenocarcinoma MCF-7 adr ; Cells, " Journal of Medicinal Chemistry, 40, 2102-2106 1997 ; . K. He, G. Shi, G.-X. Zhao, L. Zeng, Q. Ye, J.T. Schwedler, K.V. Wood, and J.L. McLaughlin * , "Three New Adjacent Bis-tetrahydrofuran Acetogenins with Four Hydroxyl Groups from Asimina triloba, " Journal of Natural Products, 59, 1029-1034 1996. BJM June 7, 2003; 326: Original investigation, first author Nicola J Cooper, University of Leicester, UK. bmj cgi content full 326 7401 1235 An accompanying commentary pp 1249-40 by Lucy Hansen, University of Edinburgh ; concerned the need to determine who benefits most from flu treatments: No studies have compared the response to treatment in vaccinated vs unvaccinated elderly residential patients. One study of vaccinated patients reported a 92% relative reduction. We often forget that the vaccine is only70% effective, and has only short term benefits. "Rather than neuraminidase inhibitors being an alternative to vaccination, they might be an additional treatment in high risk groups, particularly during epidemics or local outbreaks." Comment: I believe there may be a limited application of these drugs. Oral Tamiflu oseltamivir ; would seem to be more advantageous. It is easier to take and more acceptable to patients. Choosing individuals for whom the drugs are indicated would be a clinical-judgment call, depending largely on cost, personal preference, and likelihood of severe complications from flu. This is another study citing misleading relative reductions in risk rather than absolute reductions. The 2003 PDR provides additional information: Gives no indication for use of zanamivir for prophylaxis. Prophylactic oseltamivir given for up to 42 days in community outbreaks reduced infection incidence from 4.8% to 1.2%. Given in nursing home residents, reduced infection rate from 4.2% to 0.4%. The majority of these had received vaccine. ; For household contacts, incidence reduced from 10% to 1%. The number needed to treat to prevent one person from getting flu varied from 11 to 28. The results cited in the article are tenuous, especially those citing effects of the drugs in preventing complications which result in antibiotic use. Tamiflu costs $60 for 75 mg twice daily for 5-days Relenza diskhaler costs $48 for 5 mg inhaled twice daily for 10 days. total of 20 inhalations and glyburide and evista, for example, evusta problem. Beating Osteoporosis Naturally By Steven Coward, ND Asheville Citizen-Times May 2003 Osteoporosis, characterized by reduced bone density and increased fracture risk, is arguably the greatest health concern of postmenopausal women. As many as 25 million Americans are thought to have osteoprosis, and 430, 000 per year will facture a bone because of it. More women die from osteoporosis than from breast cancer, uterine cancer, and ovarian cancer combined. Hormone replacement therapy with estrogen has long been the conventional treatment, and newer drugs like Fosamax and Evisra are being used more and more. The problems with these are that they have undesirable side effects and they fail to address the basic natural processes that govern bone health. Fortunately, it is easy to keep your bones healthy and strong without drugs. Simply work them and feed them! Weight-bearing exercise is the cornerstone of good bone health. Our skeletons adapt to the demands put upon them. If we work them, they will get, and stay, strong. Consider a 1994 study in the New England Journal of Medicine that put a group of frail elderly women on a twice-per-week progressive strength training program for one year. Some of these people were in their nineties! Nevertheless, their bone density increased 1% on average. A control group that did not engage in strength training lost more than 2% of its bone density on average, typical for postmenopausal women. Incidentally, the group that did strength training saw improvement in balance, which reduces fracture risk, and a 27% increase in overall activity. How are those for side effects. These elders not only began to get their bones back, but their lives too! If this group could do it, so can you. Many other studies have replicated these findings, and others have proved the converse true. Healthy volunteers assigned to twelve weeks of bed rest, for example, lost almost 4% of their bone density at the hip. Use it or lose it! How do we feed our bones to keep them healthy? Everyone knows calcium is important. I prefer food sources because they contain a host of other nutrients in addition to calcium. Our bones are made up of much more than just calcium, and we need to get balanced nutrition to remain healthy. Cheese, yogurt and milk are high in calcium, and organic is preferable to avoid traces of artificial hormones and antibiotics. For those who don't tolerate milk well, there are vegetable sources. Spinach is a well-known source, but turnip greens, collard greens, and rhubarb are even richer. Lambs quarters, broccoli, and tofu are other good sources. In order to absorb our calcium, we need vitamin D. Our bodies manufacture vitamin D when our skin is exposed to sunlight. We can get all we need with 30% of our skin exposed to sunlight for 30 minutes per day without sunscreen. One teaspoon of cod liver oil gives a full day's supply, as does four ounces of sardines or mackerel. Other fish and mushrooms are good sources as well.

Evista osteopenia Opinion paper, which states that second-generation antipsychotics differ in their diabetes risk profiles. These findings are in direct conflict with the FDA's recent class labeling language. Despite an increasingly competitive environment, we believe the product, together with Symbyax, still has sales growth potential in the U.S. We expect U.S. sales to benefit from the recent approval of a bipolar maintenance indication and the anticipated near-term approval of Zyprexa IntraMuscular. Sales outside the U.S. increased 42 percent, to $1.64 billion. Excluding the impact of exchange rates, our sales outside the U.S. grew 26 percent. The strong international sales growth of Zyprexa was primarily driven by increased unit volume attributable to the bipolar mania indication and the ongoing conversion from typical to atypical antipsychotics and, to a lesser extent, the impact of exchange rates. Zyprexa recorded strong growth in several key markets, including several major European Union countries and in Japan. We expect continued strong overseas growth of the product in 2004. Zyprexa recently received U.S. and European approvals for bipolar maintenance. Zyprexa IntraMuscular has recently been launched in Australia, Canada, and Europe, and we currently expect U.S. approval in the first half of 2004. Diabetes care products, composed primarily of Humulin, biosynthetic human insulin; Humalog, our insulin analog; and Actos, an oral agent for the treatment of type 2 diabetes, had aggregate worldwide revenues of $2.57 billion in 2003, an increase of 12 percent. Diabetes care revenues in the U.S. increased 10 percent, to $1.57 billion. Diabetes care revenues outside the U.S. increased 17 percent, to $1.00 billion. Humulin had worldwide sales of $1.06 billion, an increase of 6 percent. Humulin sales in the U.S. decreased 2 percent, to $507.5 million. Humulin sales outside the U.S. increased 13 percent, to $552.9 million. Humalog became a billion-dollar product in 2003 with worldwide sales of $1.02 billion, an increase of 22 percent. Humalog sales in the U.S. increased 25 percent, to $658.6 million. Humalog sales outside the U.S. increased 19 percent, to $362.7 million. In 2004, we expect our worldwide insulin franchise to have little or no growth primarily due to expected continued competitive pressure on prescription volume. Actos revenues, the majority of which represent service revenues from a copromotion agreement in the U.S. with Takeda Pharmaceuticals North America Takeda ; , increased 10 percent in 2003, to $431.2 million. Actos is manufactured by Takeda Chemical Industries, Ltd., and sold in the U.S. by Takeda. Gemzar became a billion-dollar product in 2003 with worldwide sales of $1.02 billion, an increase of 17 percent. Sales in the U.S. increased 8 percent, to $522.4 million. Sales outside the U.S. increased 27 percent, to $499.3 million. We recently submitted Gemzar in the U.S. for the treatment of late-stage metastatic breast cancer. Dvista had worldwide sales of $922.1 million in and hydrochlorothiazide. Do not use more of this medicine and do not use it more often than your doctor ordered. Zi-Fa Wang, Chang Liu, Yi Lu, Rui Dong, Jun Xu, Liang Yu, Ying-Min Yao, Qing-Guang Liu, Cheng-En Pan, Department of Surgery, First Hospital, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China Zi-Fa Wang, Now is in the Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA Correspondence to: Dr. Zi-Fa Wang, Department of Surgery, University of Pittsburgh, NW607, Montefiore University Hospital, 3459 Fifth Avenue, Pittsburgh, PA 15213, United States. ziw3 pitt Telephone: + 1-412-343-9407 Fax: + 1-412-647-5959 Received: 2003-05-10 Accepted: 2004-01-29.

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